Baritor 2mg Tablet

Baritor 2mg Tablet

Baritor tablet is indicated for the treatment of adult patients with moderate to severely active Rheumatoid Arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies.

Limitation of Use: Use of Baritor in combination with other JAK inhibitors, biologic DMARDs or with potent immunosuppressants such as Azathioprine and cyclosporine is not recommended.

Pharmacology

Baricitinib is a selective and reversible inhibitor of Janus kinase JAK1 and JAK2. Janus kinases (JAKs) are enzymes that transduce intracellular signals from cell surface receptors for a number of cytokines and growth factors involved in haematopoiesis, inflammation and immune function.

Interaction

Strong OAT3 Inhibitors: Baritor exposure is increased when it is co-administered with strong OAT3 inhibitors (such as probenecid).

Other JAK Inhibitors or Biologic DMARDs: Baritor has not been studied in combination with other JAK inhibitors or with biologic DMARDS.

Contraindications

• Anemia: Avoid initiation or interrupt Baricitinib in patients with hemoglobin less than 8 g/dL.
• Lymphopenia: Avoid initiation or interrupt Baricitinib in patients with an Absolute Lymphocyte Count less than 500 cells/mm3.
• Neutropenia: Avoid initiation or interrupt Baricitinib in patients with an Absolute Neutrophil Count less than 1000 cells/mm3.

Side Effects

The most commonly reported adverse drug reactions (ADRs) occurring in 2% of patients treated with Baritor monotherapy or in combination with conventional synthetic DMARDs were increased LDL cholesterol (33.6%), upper respiratory tract infections (14.7%) and nausea (2.8%).

Pregnancy & Lactation

Baricitinib is contraindicated during pregnancy. No information is available on the presence of Baricitinib in human milk.

Overdose Effects

In case of an overdose, it is recommended that the patient should be monitored for signs and symptoms of adverse reactions. Patients who develop adverse reactions should receive appropriate treatment.

Therapeutic Class

Immunosuppressant

Storage Conditions

Store at or below 30°C temperature. Keep away from light and wet place. Keep out of reach of children.