Sonap 500mg Tablet

Sonap 500mg Tablet

Sonap is indicated for the relief of sign and symptoms of-

• rheumatoid arthritis
• osteoarthritis
• ankylosing spondylitis
• juvenile arthritis
• tendonitis
• bursitis
• acute gout
  It is also indicated for the management of primary dysmenorrhea & pain.

Pharmacology

As with other non-selective NSAIDs, naproxen exerts it's clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. Although both enzymes contribute to prostaglandin production, they have unique functional differences.

Interaction

ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.

Antacids & Sucralfate: delay the absorption of Sonap.

Aspirin: increase adverse effects.Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.

Methotrexate: enhance the toxicity of Methotrexate.

Warfarin: increase the risk of GI bleeding.

Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.

Contraindications

Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Side Effects

Most frequently reported side effects include following:

• Gastrointestinal:
• Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
• Central Nervous System: Headache, vertigo, drowsiness.
• Dermatological: Pruritus (itching), purpura.
• Cardiovascular: Edema, palpitation.Others: Visual disturbances, hearing disturbances.

Pregnancy & Lactation

Most non-steroidal anti-inflammatory drugs may have an adverse effect on the fetus through their pharmacological properties. Naproxen causes a delay in parturition in animals and has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen. 

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)Storage ConditionsKeep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.