Naprosyn 500mg Tablet

Naprosyn 500mg Tablet

As with other non-selective NSAIDs, naproxen exerts it's clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. Although both enzymes contribute to prostaglandin production, they have unique functional differences.

Indications

Naprosyn is indicated for the relief of sign and symptoms of-

• rheumatoid arthritis
• osteoarthritis
• ankylosing spondylitis
• juvenile arthritis
• tendonitis bursitis
• acute gout
  It is also indicated for the management of primary dysmenorrhea & pain.

Contraindications

Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.

Side Effects

Most frequently reported side effects include following:

• Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia.
• Central Nervous System: Headache, vertigo, drowsiness.
• Dermatological: Pruritus (itching), purpura. Cardiovascular: Edema, palpitation.
• Others: Visual disturbances, hearing disturbances.

Pregnancy & Lactation

Most non-steroidal anti-inflammatory drugs may have an adverse effect on the fetus through their pharmacological properties.

Precautions & Warnings

Renal effects: As with other non-steroidal anti- inflammatory drugs, long-term administration of naproxen to animal has resulted in renal papillary necrosis and other abnormal renal pathology.

Therapeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.