Ariprex 10mg Tablet

Ariprex 10mg Tablet

Indications

Ariprex is indicated for-

• Schizophrenia
• Bipolar disorder
• Adjunctive treatment of major depressive disorder
• Irritability associated with autistic disorder
• Agitation associated with schizophrenia or bipolar mania

Pharmacology

Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.

Administration

Oral formulations: Administer once daily without regard to meals.

IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg.

Interaction

Caution should be exercised when Ariprex is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Ariprex clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Ariprex elimination and cause increased blood levels.

Contraindications

Known hypersensitivity to Aripiprazole.

Side Effects

Vomiting, nausea, akathisia, extrapyramidal disorder, somnolence, sedation, dizziness, insomnia, tremor, restlessness, fatigue, blurred vision, salivary hypersecretion, constipation, pyrexia, drooling, decreased appetite.

Pregnancy & Lactation

Pregnancy category C. It should be avoided during pregnancy. It is recommended that women receiving Aripiprazole should not breast-feed.

Overdose Effects

Ariprex at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Ariprex overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.

Therapeutic Class

Atypical neuroleptic drugs

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.