Fosfomax 4gm/vial Injection

Fosfomax 4gm/vial Injection

Fosfomax IV Infusion is indicated for the treatment of the following infections in adults and children including neonates:

• Osteomyelitis
• Complicated urinary tract infections
• Nosocomial lower respiratory tract infections
• Bacterial meningitis
• Bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above

Pharmacology

Fosfomycin exerts a bactericidal effect on proliferating pathogens by preventing the enzymatic synthesis of the bacterial cell wall. Fosfomycin inhibits the first stage of intracellular bacterial cell wall synthesis by blocking peptidoglycan synthesis.

Interaction

No drug-drug interaction studies have been performed with fosfomycin.

Contraindications

Hypersensitivity to the active substance, fosfomycin, or to any of the excipients.

Side Effects

The most commonly reported adverse reactions during treatment are gastrointestinal disturbances and injection site reactions. Other important adverse reactions include hypokalaemia and/or hypernatraemia.

Use in Special Populations

No clinical data on pregnancies are available. Fosfomax should therefore not be prescribed to pregnant women unless the benefit outweighs the risk. After the administration of Fosfomax, low quantities of fosfomycin were found in human milk. Fosfomax should therefore not be administered during lactation unless the benefit outweighs the risk.

Overdose Effects

Experience regarding the overdose of fosfomycin is limited. Cases of hypotonia, somnolence, electrolytes disturbances, thrombocytopenia and hypoprothrombinemia have been reported with parenteral use of fosfomycin.

Therapeutic Class

Intracellular antibiotic

Storage Conditions

Store below 30° C temperature, protect from light & moisture. Keep out of the reach of children. After being mixed with solvent this medicine should be used immediately or stored in a refrigerator (at 2-8°C) protected from light for up to 24 hours.